Perricone Cold Plasma Review

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Editor Rating:
3.8 / 5.0
Rating: 3.8/5.
By: Brittany Kline

Perricone Cold Plasma Plus+ Overview

Supposedly it’s a multi-tasking, miracle-working, all-in-one powerhouse cream, but can one little jar really do it all?
Whether your skin needs a little pick-me-up or a complete overhaul, Dr. Perricone’s Cold Plasma Plus+ anti-wrinkle cream promises to give you exactly what you need. The patented liquid crystal delivery system with advanced lipid transport ensures that your skin will receive the exact amount of moisture and nutrients it needs in order to stay soft and look youthfully firm.

A Closer Look at Perricone Cold Plasma Plus+

Perricone MD Cold Plasma sounds like a miracle in a jar and comes with an incredibly high price tag for most customers. Those looking to improve their beauty on a budget may have a hard time keeping their supply current. Aside from the hefty price tag, the biggest complaint from user reviews was the cream’s strong, fishy odor. This likely comes from the source providing all of the included omega 3s and is a natural smell, rather than a sign of any ill effects. Still, the smell has been described as unpleasant, particularly for use on the face and around the nose.

Omega-3 fatty acids enhance skin's natural radiance.

A slight odor might be worth the potential benefits, however. Perricone Cold Plasma Plus+ claims to battle nine of the most visible signs of aging, namely: loss of radiance, uneven skin tone and texture, discoloration or spottiness, ruddiness, enlarged pores, fine lines, deep wrinkles, and loss of firmness. One product claiming to address so much is a rather large promise, and if it really can do so much, it might just be worth a little funk and a big price.

Most of the science behind the active ingredients in the Cold Plasma cream is fairly sound; however one of the ingredients might be a cause for concern amongst some consumers. One of the preservatives in the cream, phenoxyethanol, has shown a wide range of adverse effects ranging from minor skin irritation to cancer risks and neurological degradation in lab studies.


  • Contains Omega-3s, -6s, & -9s
  • Utilizes skincare powerhouse Retinyl
  • Customers report light-weight and non-greasy skin-feel


  • Strong fishy odor
  • Some customers report redness and itching after use
  • Price might be a challenge for the average beauty-seeker
  • Any benefits gained might take much longer than advertised

Key Ingredients

Most of the ingredients included in Perricone Cold Plasma Plus+ are intended to be helpful to the skin. Of course, this is the intention of the product, so that makes perfect sense. However, there are a few outliers which raise red flags, such as Ceteareth-20 and Phenoxyethanol. Apart from being chemical concoctions which mean nothing when tacked on to a huge laundry list, they aren’t so stellar when put under the microscope themselves. Below, we break down some of the best- and worst- ingredients in this so called all-in-one powerhouse cream.


While this one might be a tongue twister, Phosphatidylcholine is actually an incredibly common substance. So common, in fact, that you might have had some for breakfast. It’s found in everyday foods such as eggs, soybeans, mustard, and sunflowers. It’s a natural alternative to penetrating chemicals, and since it binds so well to water, it helps deliver a powerful dose of essential nutrients deep into the skin.

Dimethyl MEA (DMAE)

DMAE is a derivative of vitamin B, and is often taken as an oral supplement to improve alertness. In skin care products, DMAE has been shown to have skin-calming effects, and restore some firmness. It also helps to improve the skin’s contour, lift, and tone. However, to retain efficacy and stability, DMEA must be contained in an environment with a pH level of ten. That is highly alkaline, and not good for skin. To put it into perspective, the average person’s skin has a pH level of five to six, just a little acidic. Bleach has a pH level of ten. DMAE thrives and functions best in a pH level of ten. That means, to reap the full benefits of DMAE, the product containing it must have a pH level similar to household bleach. Since I’m hoping that’s not the case, then we can only assume that Perricone Cold Plasma Plus+ does not reap the full effect of DMAE.

Dihydroxyacetone (DHA)

This natural carbohydrate is an essential fatty acid which delivers a superior level of hydration. It is often used in tanning formulas, and regulates skin-staining thanks to its ability to permeate the dermis. While generally well-tolerated and anti-reactionary, DHA usually doesn’t coexist well with most SPF, so it is recommended to apply additional SPF when utilizing anything with DHA.


Commonly found in soy products, nuts, and some dairy products, this amino acid is produced in our bodies naturally. When applied in additional amounts, it helps brighten overall skin tone. This is because L-Tyrosine helps stimulate the production of melanin, the pigment which colors our skin. It is also thought to help create more collagen as well, especially when used alongside ascorbic acid.

Full List of Ingredients

Water/Aqua/Eau, Glycerin, Isopropyl Palmitate, Cetearyl Alcohol, Glyceryl Stearate, PEG-100 Stearate, Butylene Glycol, Phosphatidylcholine, Tetrahexyldecyl Ascorbate, Dimethyl MEA, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-3, Tyrosine, Glycolic Acid, Helianthus Annuus (Sunflower) Seed Oil, Magnesium Aspartate, Zinc Gluconate, Rosmarinus Officinalis (Rosemary) Leaf Extract, Copper Gluconate, Sodium Hyaluronate, Retinyl Palmitate, Echium Plantagineum Seed Oil, Hydrolyzed Myrtus Communis Leaf Extract, Copper Tripeptide-1, Dimethicone, Disodium EDTA, Carbomer, Ceteareth-20, Cyclopentasiloxane, Caprylyl Glycol, Cetearyl Alcohol, Cyclohexasiloxane, Polysorbate 20, Zea Mays (Corn) Oil, Phenoxyethanol, Sorbic Acid

Directions: How to Use Perricone Cold Plasma Plus+

Cleanse your skin thoroughly before applying Perricone MD Cold Plasma. Apply once in the morning and once in the evening. The best possible results will be seen when this cream is used in conjunction with a full beauty regimen.
Perricone MD contains phenoxyethanol, a known skin irritant. If irritation occurs, discontinue use. It is highly recommended to test this on a small, easy to cover portion of the skin prior to regular use.

The Final Word on Perricone Cold Plasma Plus+

There is an incredible amount of science in Perricone Cold Plasma Plus+, which is to be expected from a formula created by a doctor. However, some of the science just does not work out correctly. We don’t know the pH of the final product, and thus can’t know how effective some of the key ingredients are. While many users swear that Perricone Cold Plasma Plus+ works wonders, several others also claim they have seen lackluster results or worse, irritation. There’s something slightly fishy about Perricone Cold Plasma Plus+, and it is not just the smell.

For more reviews and answers to all of your burning skincare questions, take a look at our other beauty articles!


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